Thursday, 13 May 2010
Abstract of Phase II Trial Results for Low Dose Naltrexone (LDN) for Crohn's Disease from Dr Jill Smith, Penn State University
Abstract Link
Summary -
http://www.medpagetoday.com/MeetingCoverage/DDW/19885
Remicade + azathioprine managed roughly 50% remission after 26 weeks, but that is of course at a big price financially and in terms of side-effects -
http://www.webmd.com/ibd-crohns-disease/crohns-disease/news/20100414/combination-therapy-treats-crohns-disease
Obviously a Phase III study will be interesting now as it will have a much bigger patient population and maybe run longer too.
Would be interesting to see how the remission rate is after another 3 months.
Would be even more interesting to see how it was if the patients were allowed to decrease dose too.
Note that Dr Smith has another study starting on Vitamin D with Crohn's too.
This is a highly significant result for Low Dose Naltrexone as it's a Phase II study which was carried out under randomised, double-blind, placebo-controlled conditions.
Summary -
45% of 40 patients achieved remission inside 12 weeks.
(Note, clinical experience shows it can take more than 3 months to really get results with LDN and certainly 4.5mg is often too high a dose too).
82% of the 40 patients had their Crohn's improve by around 20% or more in terms of its activity.
Healing was reported in the endoscopy studies too.
Although this is not quite as impressive a result as the first study, it is at least as good as many other treatments and with a lot, lot less side effects (Only reversible liver enzyme changes reported).
For comparison, this anti-TNF treatment managed 40% remission after 5 years, chances are LDN could be 5%+ better than that :
Healing was reported in the endoscopy studies too.
Although this is not quite as impressive a result as the first study, it is at least as good as many other treatments and with a lot, lot less side effects (Only reversible liver enzyme changes reported).
For comparison, this anti-TNF treatment managed 40% remission after 5 years, chances are LDN could be 5%+ better than that :
http://www.medpagetoday.com/MeetingCoverage/DDW/19885
Remicade + azathioprine managed roughly 50% remission after 26 weeks, but that is of course at a big price financially and in terms of side-effects -
http://www.webmd.com/ibd-crohns-disease/crohns-disease/news/20100414/combination-therapy-treats-crohns-disease
Obviously a Phase III study will be interesting now as it will have a much bigger patient population and maybe run longer too.
Would be interesting to see how the remission rate is after another 3 months.
Would be even more interesting to see how it was if the patients were allowed to decrease dose too.
Note that Dr Smith has another study starting on Vitamin D with Crohn's too.
Tuesday, 27 April 2010
2nd European Low Dose Naltrexone Conference Summary
Hi, below is a copy of the live tweeting LDN Now Scotland from did the 2nd European Low Dose Naltrexone Conference in Glasgow, Scotland on 24th April 2010.
These were originally published via twitter at -
http://twitter.com/LDNNow
@tomgilhooly Opening the conferenceLDN Now "Troublemakers" "Agitators" ! hehe #bigonldn20102:18 AM Apr 24th via Tweetie
Importance of patient groups being talked about. #bigonldn2010#ldnnow2:19 AM Apr 24th via Tweetie
Dr Tom looking for a Glasgow based Neurologist in order to get funding for MS trial. #bigonldn20102:20 AM Apr 24th via Tweetie
Stephen Dickson of Dickson's Pharnacy up first on#lowdosenaltrexone dispensing. #bigonldn20102:21 AM Apr 24th via Tweetie
2500+ #lowdosenaltrexone patients on Dickson's books200 Drs 2008 now 683 in A Dr Wright using it for varied conditions#bigonldn20102:24 AM Apr 24th via Tweetie
Stable #lowdosenaltrexone supply chain in UKDrug interactions and adverse reactions more common (Because of more use) Useful#bigonldn20192:25 AM Apr 24th via Tweetie
More neurologists referring GP to prescribe #lowdosenaltrexone#bigonldn20102:26 AM Apr 24th via Tweetie
More #lowdosenaltrexone / ALA for cancer treatment.#bigonldn2010 99 LDN phone calls on one Saturday.2:28 AM Apr 24th via Tweetie
Feedback on #lowdosenaltrexone very positive. #bigonldn20102:29 AM Apr 24th via Tweetie
Dickson's now supplying #lowdosenaltrexone cream for children.#bigonldn20102:31 AM Apr 24th via Tweetie
No placebo response from Autistic kids on #lowdosenaltrexoneCompelling efficacy evidence. #bigonldn20102:32 AM Apr 24th via Tweetie
Type 1 diabetes and depression now being treated successfully with #lowdosenaltrexone #bigonldn20102:33 AM Apr 24th via Tweetie
34 yr old ME patient1 month on 3mg #lowdosenaltrexone Good response.2:34 AM Apr 24th via Tweetie
Developed inflammatory response on #lowdosenaltrexone which went away when LDN stopped and returned on LDN #bigonldn20102:35 AM Apr 24th via Tweetie
Perhaps #lowdosenaltrexone triggered response to underlying infection not being fought without LDN #bigonldn20102:36 AM Apr 24th via Tweetie
Patient reported elimination of allergies and need for asthma inhaler on #lowdosenaltrexone #bigonldn20102:37 AM Apr 24th via Tweetie
Can still take many drugs with #lowdosenaltrexone e.gMesalazine , azathioprine (Stable dose), interferon and copaxone#bigonldn20102:39 AM Apr 24th via Tweetie
Anti-convulsants and epiliptic drugs generally ok with#lowdosenaltrexone too #bigonldn20102:40 AM Apr 24th via Tweetie
Inadvisable with #lowdosenaltrexone Roaccutane (No info available) , MST, SR Morphine, Fentanyl, Ketamine #bigonldn20102:42 AM Apr 24th via Tweetie
#vitaminD a key additional treatment for MS (And others)2:54 AM Apr 24th via web
Study shows that Vitamin D dramatically reduces the production of inflammatory LT #bigonldn20102:56 AM Apr 24th via web
Likely that Vitamin D alone may slow down progression of #MS due to the suppression of the inflammatory response #bigonldn20102:58 AM Apr 24th via web
Gene expression affected by Vitamin D - less vitamin D -> more likely to develop #MS #bigonldn2010 - Stephen Dickson2:59 AM Apr 24th via web
'Resveratrol', being investigated as anti-ageing agentNeuro protective effects being reported on now. #bigonldn2010 #MS3:00 AM Apr 24th via web
#Resveratrol immunomodulates the immune response in a way which is neuro-protective for #MS #bigonldn20103:01 AM Apr 24th via web
#Resveratrol causes death of immune response cells, so potentially useful for treatment of autoimmune and inflammatory disease#bigonldn20103:02 AM Apr 24th via web
#reveratrol study going on now at University of MissouriInterim conclusion - useful for neurodegenerative diseases #bigonldn20103:04 AM Apr 24th via web
#resveratrol generally seems to reduce mortalityObese mice lived as long as healthy ones on this drug. #bigonldn20103:04 AM Apr 24th via web
#resveratrol 1000-1500mg per day dosage. #bigonldn20103:06 AM Apr 24th via web
Other useful supplements - Alpha-Lipoic Acid, L-carnitine, Beta-D- Glucan and chromium, Green Tea #bigonldn20103:08 AM Apr 24th via web
Pat Crowely now, on his experience with #lowdosenaltrexone in Ireland #bigonldn20103:38 AM Apr 24th via web
Over 30 deaths in the EU from Tysabri for #MS #bigonldn20103:41 AM Apr 24th via web
Example of the situation with #lowdosenaltrexone Triple therapy for gastric ulcers, ridiculed but ultimately Nobel prize #bigonldn20103:47 AM Apr 24th via web
(Recommendation from @tomgilhooly on Vitamin D - Get your GP to test Vit D level in summer and winter & take up to 4000IU/day#bigonldn2010)3:48 AM Apr 24th via web
(Get your Vitamin D level up to 100) #bigonldn20103:49 AM Apr 24th via web
Low Omega 3 levels in MS patient a problem, also noticed patient with #MS and very high iron levels. #bigonldn20103:50 AM Apr 24th via web
#lowdosenaltrexone highly useful for middle aged #MS females with PPMS #bigonldn20103:50 AM Apr 24th via web
(Quote from Machiavelli on the difficulty of usurping an existing system - e.gNon #lowdosenaltrexone therapies with LDN)#bigonldn20103:52 AM Apr 24th via web
Dr Paulo Zamboni - Liberation treatment CCSVI #bigonldn20103:54 AM Apr 24th via web
#bigonldn2010 #lowdosenaltrexone EU ConfL-R Stephen Dickson, @tomgilhooly Dr Bob LawrencePat Crowely presentinghttp://yfrog.com/5xfubj3:55 AM Apr 24th via Tweetie
[Talking about the efforts pharma companies make to play down CCSVI and LDN in favour of their products] #bigonldn20104:00 AM Apr 24th via web
Non of Dr Bihari's #MS work on #lowdosenaltrexone was allowed to be published.4:01 AM Apr 24th via web
One medic who was pro #lowdosenaltrexone now describes it as useless (He is now a main player in Tysabri in Ireland,Go figure)#bigonldn20104:02 AM Apr 24th via web
DrJeffrey Dach #lowdosenaltrexone 'greatest medical discovery of the [20th] century' #bigonldn20104:03 AM Apr 24th via web
#lowdosenaltrexone is a 'mass movement driven by people [not pharma]'4:03 AM Apr 24th via web
Pat unable to prescribe #lowdosenaltrexone for #crohns due to lack of co-operation by GI consultants who are resistant. #bigonldn20104:04 AM Apr 24th via web
#ldnnow comment - As ever, the picture is one where those who know about #lowdosenaltrexone and use it are positive.#bigonldn20104:05 AM Apr 24th via web
#ldnnow comment - Those who are ignorant of #lowdosenaltrexoneare skeptical but won't try it. #bigonldn20104:06 AM Apr 24th via web
Big problem is lack of knowledge of #lowdosenaltrexone in doctors.#bigonldn20104:08 AM Apr 24th via web
10,000 #MS patients in Ireland and less than 40 neurologists - less than the Czech Republic #bigonldn20104:10 AM Apr 24th via web
Talking about @ldndatabase proposal for #lowdosenaltrexoneresearch in Ireland #bigonldn20104:11 AM Apr 24th via web
Vote now for @ldndatabase proposal for 500K GBP for#lowdosenaltrexone research - http://bit.ly/chjraq #bigonldn20104:12 AM Apr 24th via web
Dr Pat Crowley presentation endsZoe Cameron, #crohn's patient on #lowdosenaltrexone speaking next. #bigonldn20104:15 AM Apr 24th via web
Zoe speaking of her diaries she kept throughout her experience of#crohn's disease and #lowdosenaltrexone #bigonldn20104:15 AM Apr 24th via web
#bigonldn2010 A #crohn's patient's experience on#lowdosenaltrexone http://yfrog.com/juo40zj4:16 AM Apr 24th via Tweetie
Zoe had food poisoning from undercooked chicken which did not improve which led to #crohn's diagnosis. #bigonldn20104:17 AM Apr 24th via web
Zoe improved on #prednisolone for #crohn's with side-effects, coming off steroids #crohn's returnedYo yo of steroids on/off#bigonldn20104:18 AM Apr 24th via web
Speaking of the sadness of the possible outcomes with #crohn's and the dark humour of patients #bigonldn20104:19 AM Apr 24th via web
Trying all sorts of diets and regimes, including no yeast, liquid only diet etcfor #crohn's #bigonldn20104:20 AM Apr 24th via web
Went from 10 1/2 stone (5 foot 8), down to 7 stone (BMI 14), hospitalisation mooted by DrsSerious conditon. #bigonldn20104:21 AM Apr 24th via web
Then terrified of eating with #crohn's Drs critisised Zoe for trying alternatives to immuno-suppresants #bigonldn20104:23 AM Apr 24th via web
Zoe's uncle, a US Dr suggested #lowdosenaltexone GP was intrigued and willing to try LDN on routine blood tests and weigh-ins#bigonldn20104:24 AM Apr 24th via web
Interrupted sleep side effect of #lowdosenaltrexone seemed minor compared to 10 crohn's trips to the toilet per night #bigonldn20104:25 AM Apr 24th via web
By week 3 on #lowdosenaltrexone Zoe gained weightAfter a few months GP told her to 'avoid doctors'! Much better. #bigonldn20104:26 AM Apr 24th via web
After a year,could eat salad & popcornNow eats what she wants and only has symptoms when run down #lowdosenaltrexone#bigonldn2010 #crohns4:28 AM Apr 24th via web
Q & A Interferons and #lowdosenaltrexone ? Dr Bob Lawrence - Not compatible. #bigonldn20104:31 AM Apr 24th via web
#lowdosenaltrexone Q&A before lunch. #bigonldn2010http://yfrog.com/2om71uj4:31 AM Apr 24th via Tweetie
Dr Pat Crowley - No interferons with #lowdosenaltrexone but safe to try it for a month and see. #bigonldn2010 Stephen Dickson agrees.4:31 AM Apr 24th via web
Q - How do we know #lowdosenaltrexone doesn't just make the patient 'feel' better only due to endorphins? #bigonldn20104:32 AM Apr 24th via web
A - Zoe - With #crohn's gained weight on #lowdosenaltrexone and bad symptom days very few and far between #bigondldn20104:33 AM Apr 24th via web
A - @tomgilhooly google 'Dr Jill Smith Low Dose Naltrexone' Compelling results. #lowdosenaltrexone #bigonldn20104:34 AM Apr 24th via web
#ldnnow comment, Dr Jill Smith's double-blind, placebo-controlled, randomised trial for #crohn's and #lowdosenaltrexone in May#bigonldn20104:34 AM Apr 24th via web
#ldnnow comment - Dr Smith's study will be presented at a conference in May 2010 #crohn's #lowdosenaltrexone#bigonldn20104:36 AM Apr 24th via web
Q - Prednisolone, restrict to 10mg or OK to go higher as Dr Zagon says is OK? #bigonldn2010 #lowdosenaltrexone4:41 AM Apr 24th via web
A - Dr Tom - Dr Ian Zagon most knowledgeable about#lowdosenaltrexone So no reason to disagree with him.#bigonldn20104:42 AM Apr 24th via web
Q - Dr Ian Zagon, OK to take CRABB drugs with#lowdosenaltrexone #bigonldn20104:42 AM Apr 24th via web
A - Dr Tom - Need to remember though that Dr Zagon is a researcher rather than an medical doctor #bigonldn2010#lowdosenaltrexone4:43 AM Apr 24th via web
RT @DiamonDie: Tom Gilhooly thinks Crohn's and CFS/ME are two conditions that respond the best to LDN: IMO it works better in MS than CF ...4:43 AM Apr 24th via web
(i.eClinical experience can sometimes differ from research environment) #ldnnow comment - Difficult for patients to know what to do.4:45 AM Apr 24th via web
Q - MS with seizures, taking #lowdosenaltrexone and anti-convulsants - can reduce anti-convulsants?4:47 AM Apr 24th via web
Q - Concerned about anti-convulsants' long-term damage to liver.#bigonldn20104:48 AM Apr 24th via web
A - Work with a neurologist to see if can be reduced and still OK on#lowdosenaltrexone #bigonldn20104:49 AM Apr 24th via web
Average Vitamin D level in Scotland 30,40 aim for 10#bigonldn2010 Can be 250 or higher though.4:52 AM Apr 24th via web
Q - #lowdosenaltrexone effective at late stages of #MS?4:55 AM Apr 24th via web
A - Dr Bob Lawrence Yes but the earlier #MS treated with#lowdosenaltrexone the better as damage is not repaired generally.#bigonldn20104:55 AM Apr 24th via web
Dr Jarred Younger's reseach on #lowdosenaltrexone for CFS/ME being unveiled at 2PM exclusively. #bigonldn20105:02 AM Apr 24th via web
Jarred Younger PhD, Rebecca McCue BS, Sean Mackey, MD, PhD - Fibromyalgia and Low Dose Naltrexone #bigonldn2010#lowdosenaltrexone6:11 AM Apr 24th via web
Preliminary results on #lowdosenaltrexone for #FM funded by Jim and Connie Binns and AFSA #bigonldn20106:15 AM Apr 24th via web
5% US women, 9 women to 1 man diagnosed with fibromyalgia#bigonldn2010 #lowdosenaltrexone6:16 AM Apr 24th via web
Muscular pain, fatigue and insomnia are main symptoms as are joint pain and headaches. #bigonldn2010 #lowdosenaltrexone6:17 AM Apr 24th via web
18 tender points, 11 are painful < 4Kg/cm^2 Diagnosis difficultControversial condition. #lowdosenaltrexone #bigonldn2010 #FM#fibro6:18 AM Apr 24th via web
Microglia cells appear to play a role in #fibromyalgia Producce TNF, IL-6, Nitric Oxide and others #bigonldn2010 #lowdosenaltrexone6:20 AM Apr 24th via web
When ill with flu, microglia cells are what produces ill feeling, tiredness and need to go to bed - useful for illness #bigonldn20106:21 AM Apr 24th via web
In #fibromyalgia microglia perform this role when no illness / hypersensitive to normal situations in body #bigonldn2010#lowdosenaltrexone6:22 AM Apr 24th via web
No existing drug modulates microglia but compounds exist which can do thisNIH research on this. #lowdosenaltrexone#bigonldn20106:25 AM Apr 24th via web
See Linda Watkins research on microglia and #lowdosenaltrexone#fibromyalgia #bigonldn20106:26 AM Apr 24th via web
Theory - #lowdosenaltrexone binds to hyper-sensitive receptors on microglia6:28 AM Apr 24th via web
Dr Jarred Younger's #lowdosenaltrexone fibromyalgia video presentationLive Q&A later. #bigonldn2010http://yfrog.com/64x7hj6:37 AM Apr 24th via Tweetie
New study - 30 women, mean age 43, no opiods, at least 6/10 on pain scale. #lowdosenaltrexone #bigonldn2010 #fibromyalgia6:39 AM Apr 24th via web
70% of #fibromyalgia patients had improvement, 50% much or very much improved on #lowdosenaltrexone (50%-75% pain reduced)#bigonldn6:41 AM Apr 24th via web
30% who had no improvement - ties in with 1st study, so consistent.#lowdosenaltrexone #bigonldn2010 #fibromyalgia6:42 AM Apr 24th via web
15% reduction in pain from placebo, additional 15% reduction due to #lowdosenaltrexone #bigonldn2010 #fibromyalgia6:43 AM Apr 24th via web
It seems that improvement persists to some extent even after#lowdosenaltrexone withdrawn. #fibromyalgia #bigonldn20106:44 AM Apr 24th via web
#lowdosenaltrexone tolerability = 89%, same as placebo in this#fibromyalgia studySo well very tolerated. #bigonldn20106:48 AM Apr 24th via web
#lowdosenaltrexone vivid dreams side-effect - 20% on placebo, 47% on LDN #bigonldn2010 Seldom disturbing dreams and tends to fade.6:49 AM Apr 24th via web
1 person dropped out of study and 1 person reduced from 5 to 3mg and did well on that. #lowdosenaltrexone #bigonldn20106:50 AM Apr 24th via web
Next steps - Further anlyses, long-term safety, mechanistic proof, optimisation #lowdosenaltrexone #fibromyalgia #bigonldn20106:51 AM Apr 24th via web
Researchers looking at levo-naltrexone and dextro-naltrexone (Left and Right parts of molecule) to optimise #lowdosenaltrexone#bigonldn20106:54 AM Apr 24th via web
Des from Fibromyalgia UK 'Very positive' on the new study results.#lowdosenaltrexone #bigonldn20106:55 AM Apr 24th via web
Skype link up with Dr Jarred Younger for Q&A being set-up now.#bigonldn2010 #lowdosenaltrexone #fibromyalgia6:59 AM Apr 24th via web
@tomgilhooly "#lowdosenaltrexone out of system in 18 hours" "Could be that effect is longer lasting" (Slow return of symptoms)#bigonldn20107:02 AM Apr 24th via web
@tomgilhooly "Study ties in with clinical experience" #bigonldn2010#lowdosenaltrexone #fibromyalgia7:03 AM Apr 24th via web
@tomgilhooly Talk of Levo/Dextro Naltrexone suggests pharma could make money out of new #Naltrexone-derived drug#bigonldn20107:04 AM Apr 24th via web
@tomgilhooly - Dextro-Naltrexone appears to be anti-inflammatory but not opiate receptor blooking #bigonldn2010#lowdosenaltrexone7:06 AM Apr 24th via web
Dr Jarred Younger - #lowdosenaltrexone and #fibromyalgia fatigue data mirrored the fatigue results very closely. #bigonldn20107:11 AM Apr 24th via web
Dosage was given 1 hour before retiring, 1 or 2 during day due to sleep problems. #lowdosenaltrexone #fibromyalgia #bigonldn20107:13 AM Apr 24th via web
Process of licensing levo and dextro naltrexone will take 'years'#bigonldn2010 #lowdosenaltrexone7:18 AM Apr 24th via web
@diamonDie presenting next on CFS/ME. #bigonldn2010 #CFS#ME #lowdosenaltrexone7:21 AM Apr 24th via web
People with CFS/ME often have many other infections and disease including auto-immune disease #bigonldn2010 #lowdosenaltrexone7:23 AM Apr 24th via web
Adrenal and other endocrine issues are also common#bigonldn2010 #lowdosenaltrexone7:23 AM Apr 24th via web
Symptoms started one day, fatigue, fever, hives, IBS, nausea, pain - feverish to this day #bigonldn2010 #lowdosenaltrexone7:24 AM Apr 24th via web
Even the smallest exertion required 24 hour restIn Finland CFS/ME is not recognised as an illness and virtually no treatment#bigonldn20107:25 AM Apr 24th via web
First heard of #lowdosenaltrexone in 2004, prescription in 2007 from Dr who had never heard of LDN #bigonldn20107:26 AM Apr 24th via web
Improvement in CFS/ME fatigue within 24 hours of#lowdosenaltrexone Much improved in first week, fever reduced#bigonldn20107:27 AM Apr 24th via web
Maija's Dr now treats many of his patients with #lowdosenaltrexoneImprovements reported from 50-70% improvement #bigonldn20107:28 AM Apr 24th via web
Patient - Could only walk '50m' now '3Km' Pain killers every day, now 1 every 2 weeks #lowdosenaltrexone #bigonldn20107:29 AM Apr 24th via web
#lowdosenaltrexone most effective for #CFS/ME but other drugs can help too. #bigonldn20107:31 AM Apr 24th via web
"Don't believe people who say there are no treatments [for CFS/ME]" #bigonldn2010 #lowdosenaltrexone7:32 AM Apr 24th via web
Maija's book on Amazon - http://bit.ly/coFtLV #bigonldn2010#lowdosenaltrexone #CFS/ME7:33 AM Apr 24th via web
Next up - Christine Fowler Chronic Fatigue Syndrome patient.#bigonldn2010 #lowdosenaltrexone7:36 AM Apr 24th via web
Don't let @diamondie fool you - she did great!7:36 AM Apr 24th via web
Christine on #lowdosenaltrexone - Now active, back to work as normal and much, much improvedLess tired. #bigonldn2010#CFS/ME7:38 AM Apr 24th via web
After 12 years of #CFS/ME on 75mg #lowdosenaltrexonerecommending anyone try it, 'shouting from the rooftops'#bigonldn20107:39 AM Apr 24th via web
Negatives - Memory still less effective and still more stressed than before #lowdosenaltrexoe #CFS/ME7:40 AM Apr 24th via web
@tomgilhooly now on #CCSVI and #lowdosenaltrexone as complimentary therapies. #bigonldn20108:10 AM Apr 24th via web
Dr Tom believes CCSVI may feed into fibromyalgia and CFS/MS too#bigonldn2010 #lowdosenaltrexone8:13 AM Apr 24th via web
Chronic Cerebrospinal Venous Insufficiency - newly identified venous conditionInternational Union of Phlebology 2009#bigonldn20108:14 AM Apr 24th via web
IUoP voted that #CCSVI was new condition #bigonldn20108:15 AM Apr 24th via web
@tomgilhooly presenting on CCSVI and #lowdosenaltrexone#bigonldn2010 http://yfrog.com/bavo4j8:18 AM Apr 24th via Tweetie
Iron Deposition in brain seen in dementia/Parkinson's and MS also in scans. #bigonldn2010 #CCSVI8:21 AM Apr 24th via web
Zivadino et al - Amount of iron deposits related to severity of MS, April 2010 #CCSVI #bigonldn20108:22 AM Apr 24th via web
Unlike #lowdosenaltrexone the MS Society in Italy are funding research (UK one isn't) and researchers are engaged.#bigonldn2010 #CCSVI8:24 AM Apr 24th via web
Zamboni April 2009 #CCSVI found in 90% of #MS patients studied.#bigonldn20108:25 AM Apr 24th via web
Zamboni Dec 2009 65 MS patient, 50% reduction in MRI lesions#CCSVI #bigonldn20108:26 AM Apr 24th via web
@rachelcreative Glad you're following and enjoying today.#bigonldn20108:27 AM Apr 24th via web in reply to rachelcreative
Zivadinov 2010 - 38% patients with single MS episode had CCSVI; 22% of non MS patients CCSVI ; 80% of severe MS patients CCSVI#bigonldn20108:29 AM Apr 24th via web
Doppler scan better than MRI for visualising #CCSVI#bigonldn20108:31 AM Apr 24th via web
A stent is a life-long procedure and complications can be serious - Venous stent can migrate to the heart #CCSVI #bigonldn20108:32 AM Apr 24th via web
CT Venogram is chosen imaging method by @tomgilhooly for#CCSVI #bigonldn20108:33 AM Apr 24th via web
#CCSVI and #lowdosenaltrexone - CCSVI is a distinct conditionIron deposit, blood/brain barrier breakdown. #bigonldn20108:34 AM Apr 24th via web
#lowdosenaltrexone immune modulator #CCSVI reduce immune stimulationNutrition important too. #bigonldn @tomgilhooly8:35 AM Apr 24th via web
#MS nutrition recommendations - Omega 3, Vitamin D, dairy-free, Inosine (Cut down Omega 6) #bigonldn2010 @tomgilhooly8:37 AM Apr 24th via web
#CCSVI - larger group of patients interested than in#lowdosenaltrexone #bigonldn20108:37 AM Apr 24th via web
#CCSVI - new condition ; Co-exists with #MS Treatment complements #lowdosenaltrexone #bigonldn2010 @tomgilhooly8:39 AM Apr 24th via web
#CCSVI risks - greatest with stent + blood thinners but still low.#bigonldn2010 @tomgilhooly8:42 AM Apr 24th via web
#CCSVI risks - new condition but treatment procedure is not a new one, proven. #bigonldn2010 @tomgilhooly8:43 AM Apr 24th via web
#CCSVI treatment very over-subscribed, a waiting list is going to be created@tomgilhooly #bigonldn20108:43 AM Apr 24th via web
#CCSVI procedure from @tomgilhooly will be cheaper than going to Poland for treatment. #bigonldn20108:47 AM Apr 24th via web
#CCSVI ultimate aim is to get procedure on the NHS in UK but need data #bigonldn2010 @tomgilhooly8:47 AM Apr 24th via web
RT @nobleday: @LDNNow SAM-e is another useful suppliment.8:55 AM Apr 24th via web
@fuwoyips EU #lowdosenaltrexone conference coverage at#bigonldn2010 hashtag8:56 AM Apr 24th via web in reply to fuwoyips
2nd European #lowdosenaltrexone conference coming to and endThanks for reading the coverage and see you again next year.#bigonldn20109:00 AM Apr 24th via web
@tomgilhooly #lowdosenaltrexone momentum from patients 'unstopable' #bigonldn20109:01 AM Apr 24th via web
Crohn's disease costs New Zealand ~ $74 milion a year in healthcare costs for around 100,000 patients.A case for#lowdosenaltrexone? #ldnnowabout 22 hours ago via web
Patient with Hashimoto's on #lowdosenaltrexone -http://proposals.yourcountryyourcall.com/ct/ct_a_view_idea.bix?i=58C09504about 19 hours ago via web
@YahooAnswersNow See @LDNNow tweets from the European#lowdosenaltrexone conference#bigonldn2010 Fibro trial results published #ldnnowabout 13 hours ago via web in reply to YahooAnswersNow
These were originally published via twitter at -
http://twitter.com/LDNNow
@tomgilhooly Opening the conferenceLDN Now "Troublemakers" "Agitators" ! hehe #bigonldn20102:18 AM Apr 24th via Tweetie
Importance of patient groups being talked about. #bigonldn2010#ldnnow2:19 AM Apr 24th via Tweetie
Dr Tom looking for a Glasgow based Neurologist in order to get funding for MS trial. #bigonldn20102:20 AM Apr 24th via Tweetie
Stephen Dickson of Dickson's Pharnacy up first on#lowdosenaltrexone dispensing. #bigonldn20102:21 AM Apr 24th via Tweetie
2500+ #lowdosenaltrexone patients on Dickson's books200 Drs 2008 now 683 in A Dr Wright using it for varied conditions#bigonldn20102:24 AM Apr 24th via Tweetie
Stable #lowdosenaltrexone supply chain in UKDrug interactions and adverse reactions more common (Because of more use) Useful#bigonldn20192:25 AM Apr 24th via Tweetie
More neurologists referring GP to prescribe #lowdosenaltrexone#bigonldn20102:26 AM Apr 24th via Tweetie
More #lowdosenaltrexone / ALA for cancer treatment.#bigonldn2010 99 LDN phone calls on one Saturday.2:28 AM Apr 24th via Tweetie
Feedback on #lowdosenaltrexone very positive. #bigonldn20102:29 AM Apr 24th via Tweetie
Dickson's now supplying #lowdosenaltrexone cream for children.#bigonldn20102:31 AM Apr 24th via Tweetie
No placebo response from Autistic kids on #lowdosenaltrexoneCompelling efficacy evidence. #bigonldn20102:32 AM Apr 24th via Tweetie
Type 1 diabetes and depression now being treated successfully with #lowdosenaltrexone #bigonldn20102:33 AM Apr 24th via Tweetie
34 yr old ME patient1 month on 3mg #lowdosenaltrexone Good response.2:34 AM Apr 24th via Tweetie
Developed inflammatory response on #lowdosenaltrexone which went away when LDN stopped and returned on LDN #bigonldn20102:35 AM Apr 24th via Tweetie
Perhaps #lowdosenaltrexone triggered response to underlying infection not being fought without LDN #bigonldn20102:36 AM Apr 24th via Tweetie
Patient reported elimination of allergies and need for asthma inhaler on #lowdosenaltrexone #bigonldn20102:37 AM Apr 24th via Tweetie
Can still take many drugs with #lowdosenaltrexone e.gMesalazine , azathioprine (Stable dose), interferon and copaxone#bigonldn20102:39 AM Apr 24th via Tweetie
Anti-convulsants and epiliptic drugs generally ok with#lowdosenaltrexone too #bigonldn20102:40 AM Apr 24th via Tweetie
Inadvisable with #lowdosenaltrexone Roaccutane (No info available) , MST, SR Morphine, Fentanyl, Ketamine #bigonldn20102:42 AM Apr 24th via Tweetie
#vitaminD a key additional treatment for MS (And others)2:54 AM Apr 24th via web
Study shows that Vitamin D dramatically reduces the production of inflammatory LT #bigonldn20102:56 AM Apr 24th via web
Likely that Vitamin D alone may slow down progression of #MS due to the suppression of the inflammatory response #bigonldn20102:58 AM Apr 24th via web
Gene expression affected by Vitamin D - less vitamin D -> more likely to develop #MS #bigonldn2010 - Stephen Dickson2:59 AM Apr 24th via web
'Resveratrol', being investigated as anti-ageing agentNeuro protective effects being reported on now. #bigonldn2010 #MS3:00 AM Apr 24th via web
#Resveratrol immunomodulates the immune response in a way which is neuro-protective for #MS #bigonldn20103:01 AM Apr 24th via web
#Resveratrol causes death of immune response cells, so potentially useful for treatment of autoimmune and inflammatory disease#bigonldn20103:02 AM Apr 24th via web
#reveratrol study going on now at University of MissouriInterim conclusion - useful for neurodegenerative diseases #bigonldn20103:04 AM Apr 24th via web
#resveratrol generally seems to reduce mortalityObese mice lived as long as healthy ones on this drug. #bigonldn20103:04 AM Apr 24th via web
#resveratrol 1000-1500mg per day dosage. #bigonldn20103:06 AM Apr 24th via web
Other useful supplements - Alpha-Lipoic Acid, L-carnitine, Beta-D- Glucan and chromium, Green Tea #bigonldn20103:08 AM Apr 24th via web
Pat Crowely now, on his experience with #lowdosenaltrexone in Ireland #bigonldn20103:38 AM Apr 24th via web
Over 30 deaths in the EU from Tysabri for #MS #bigonldn20103:41 AM Apr 24th via web
Example of the situation with #lowdosenaltrexone Triple therapy for gastric ulcers, ridiculed but ultimately Nobel prize #bigonldn20103:47 AM Apr 24th via web
(Recommendation from @tomgilhooly on Vitamin D - Get your GP to test Vit D level in summer and winter & take up to 4000IU/day#bigonldn2010)3:48 AM Apr 24th via web
(Get your Vitamin D level up to 100) #bigonldn20103:49 AM Apr 24th via web
Low Omega 3 levels in MS patient a problem, also noticed patient with #MS and very high iron levels. #bigonldn20103:50 AM Apr 24th via web
#lowdosenaltrexone highly useful for middle aged #MS females with PPMS #bigonldn20103:50 AM Apr 24th via web
(Quote from Machiavelli on the difficulty of usurping an existing system - e.gNon #lowdosenaltrexone therapies with LDN)#bigonldn20103:52 AM Apr 24th via web
Dr Paulo Zamboni - Liberation treatment CCSVI #bigonldn20103:54 AM Apr 24th via web
#bigonldn2010 #lowdosenaltrexone EU ConfL-R Stephen Dickson, @tomgilhooly Dr Bob LawrencePat Crowely presentinghttp://yfrog.com/5xfubj3:55 AM Apr 24th via Tweetie
[Talking about the efforts pharma companies make to play down CCSVI and LDN in favour of their products] #bigonldn20104:00 AM Apr 24th via web
Non of Dr Bihari's #MS work on #lowdosenaltrexone was allowed to be published.4:01 AM Apr 24th via web
One medic who was pro #lowdosenaltrexone now describes it as useless (He is now a main player in Tysabri in Ireland,Go figure)#bigonldn20104:02 AM Apr 24th via web
DrJeffrey Dach #lowdosenaltrexone 'greatest medical discovery of the [20th] century' #bigonldn20104:03 AM Apr 24th via web
#lowdosenaltrexone is a 'mass movement driven by people [not pharma]'4:03 AM Apr 24th via web
Pat unable to prescribe #lowdosenaltrexone for #crohns due to lack of co-operation by GI consultants who are resistant. #bigonldn20104:04 AM Apr 24th via web
#ldnnow comment - As ever, the picture is one where those who know about #lowdosenaltrexone and use it are positive.#bigonldn20104:05 AM Apr 24th via web
#ldnnow comment - Those who are ignorant of #lowdosenaltrexoneare skeptical but won't try it. #bigonldn20104:06 AM Apr 24th via web
Big problem is lack of knowledge of #lowdosenaltrexone in doctors.#bigonldn20104:08 AM Apr 24th via web
10,000 #MS patients in Ireland and less than 40 neurologists - less than the Czech Republic #bigonldn20104:10 AM Apr 24th via web
Talking about @ldndatabase proposal for #lowdosenaltrexoneresearch in Ireland #bigonldn20104:11 AM Apr 24th via web
Vote now for @ldndatabase proposal for 500K GBP for#lowdosenaltrexone research - http://bit.ly/chjraq #bigonldn20104:12 AM Apr 24th via web
Dr Pat Crowley presentation endsZoe Cameron, #crohn's patient on #lowdosenaltrexone speaking next. #bigonldn20104:15 AM Apr 24th via web
Zoe speaking of her diaries she kept throughout her experience of#crohn's disease and #lowdosenaltrexone #bigonldn20104:15 AM Apr 24th via web
#bigonldn2010 A #crohn's patient's experience on#lowdosenaltrexone http://yfrog.com/juo40zj4:16 AM Apr 24th via Tweetie
Zoe had food poisoning from undercooked chicken which did not improve which led to #crohn's diagnosis. #bigonldn20104:17 AM Apr 24th via web
Zoe improved on #prednisolone for #crohn's with side-effects, coming off steroids #crohn's returnedYo yo of steroids on/off#bigonldn20104:18 AM Apr 24th via web
Speaking of the sadness of the possible outcomes with #crohn's and the dark humour of patients #bigonldn20104:19 AM Apr 24th via web
Trying all sorts of diets and regimes, including no yeast, liquid only diet etcfor #crohn's #bigonldn20104:20 AM Apr 24th via web
Went from 10 1/2 stone (5 foot 8), down to 7 stone (BMI 14), hospitalisation mooted by DrsSerious conditon. #bigonldn20104:21 AM Apr 24th via web
Then terrified of eating with #crohn's Drs critisised Zoe for trying alternatives to immuno-suppresants #bigonldn20104:23 AM Apr 24th via web
Zoe's uncle, a US Dr suggested #lowdosenaltexone GP was intrigued and willing to try LDN on routine blood tests and weigh-ins#bigonldn20104:24 AM Apr 24th via web
Interrupted sleep side effect of #lowdosenaltrexone seemed minor compared to 10 crohn's trips to the toilet per night #bigonldn20104:25 AM Apr 24th via web
By week 3 on #lowdosenaltrexone Zoe gained weightAfter a few months GP told her to 'avoid doctors'! Much better. #bigonldn20104:26 AM Apr 24th via web
After a year,could eat salad & popcornNow eats what she wants and only has symptoms when run down #lowdosenaltrexone#bigonldn2010 #crohns4:28 AM Apr 24th via web
Q & A Interferons and #lowdosenaltrexone ? Dr Bob Lawrence - Not compatible. #bigonldn20104:31 AM Apr 24th via web
#lowdosenaltrexone Q&A before lunch. #bigonldn2010http://yfrog.com/2om71uj4:31 AM Apr 24th via Tweetie
Dr Pat Crowley - No interferons with #lowdosenaltrexone but safe to try it for a month and see. #bigonldn2010 Stephen Dickson agrees.4:31 AM Apr 24th via web
Q - How do we know #lowdosenaltrexone doesn't just make the patient 'feel' better only due to endorphins? #bigonldn20104:32 AM Apr 24th via web
A - Zoe - With #crohn's gained weight on #lowdosenaltrexone and bad symptom days very few and far between #bigondldn20104:33 AM Apr 24th via web
A - @tomgilhooly google 'Dr Jill Smith Low Dose Naltrexone' Compelling results. #lowdosenaltrexone #bigonldn20104:34 AM Apr 24th via web
#ldnnow comment, Dr Jill Smith's double-blind, placebo-controlled, randomised trial for #crohn's and #lowdosenaltrexone in May#bigonldn20104:34 AM Apr 24th via web
#ldnnow comment - Dr Smith's study will be presented at a conference in May 2010 #crohn's #lowdosenaltrexone#bigonldn20104:36 AM Apr 24th via web
Q - Prednisolone, restrict to 10mg or OK to go higher as Dr Zagon says is OK? #bigonldn2010 #lowdosenaltrexone4:41 AM Apr 24th via web
A - Dr Tom - Dr Ian Zagon most knowledgeable about#lowdosenaltrexone So no reason to disagree with him.#bigonldn20104:42 AM Apr 24th via web
Q - Dr Ian Zagon, OK to take CRABB drugs with#lowdosenaltrexone #bigonldn20104:42 AM Apr 24th via web
A - Dr Tom - Need to remember though that Dr Zagon is a researcher rather than an medical doctor #bigonldn2010#lowdosenaltrexone4:43 AM Apr 24th via web
RT @DiamonDie: Tom Gilhooly thinks Crohn's and CFS/ME are two conditions that respond the best to LDN: IMO it works better in MS than CF ...4:43 AM Apr 24th via web
(i.eClinical experience can sometimes differ from research environment) #ldnnow comment - Difficult for patients to know what to do.4:45 AM Apr 24th via web
Q - MS with seizures, taking #lowdosenaltrexone and anti-convulsants - can reduce anti-convulsants?4:47 AM Apr 24th via web
Q - Concerned about anti-convulsants' long-term damage to liver.#bigonldn20104:48 AM Apr 24th via web
A - Work with a neurologist to see if can be reduced and still OK on#lowdosenaltrexone #bigonldn20104:49 AM Apr 24th via web
Average Vitamin D level in Scotland 30,40 aim for 10#bigonldn2010 Can be 250 or higher though.4:52 AM Apr 24th via web
Q - #lowdosenaltrexone effective at late stages of #MS?4:55 AM Apr 24th via web
A - Dr Bob Lawrence Yes but the earlier #MS treated with#lowdosenaltrexone the better as damage is not repaired generally.#bigonldn20104:55 AM Apr 24th via web
Dr Jarred Younger's reseach on #lowdosenaltrexone for CFS/ME being unveiled at 2PM exclusively. #bigonldn20105:02 AM Apr 24th via web
Jarred Younger PhD, Rebecca McCue BS, Sean Mackey, MD, PhD - Fibromyalgia and Low Dose Naltrexone #bigonldn2010#lowdosenaltrexone6:11 AM Apr 24th via web
Preliminary results on #lowdosenaltrexone for #FM funded by Jim and Connie Binns and AFSA #bigonldn20106:15 AM Apr 24th via web
5% US women, 9 women to 1 man diagnosed with fibromyalgia#bigonldn2010 #lowdosenaltrexone6:16 AM Apr 24th via web
Muscular pain, fatigue and insomnia are main symptoms as are joint pain and headaches. #bigonldn2010 #lowdosenaltrexone6:17 AM Apr 24th via web
18 tender points, 11 are painful < 4Kg/cm^2 Diagnosis difficultControversial condition. #lowdosenaltrexone #bigonldn2010 #FM#fibro6:18 AM Apr 24th via web
Microglia cells appear to play a role in #fibromyalgia Producce TNF, IL-6, Nitric Oxide and others #bigonldn2010 #lowdosenaltrexone6:20 AM Apr 24th via web
When ill with flu, microglia cells are what produces ill feeling, tiredness and need to go to bed - useful for illness #bigonldn20106:21 AM Apr 24th via web
In #fibromyalgia microglia perform this role when no illness / hypersensitive to normal situations in body #bigonldn2010#lowdosenaltrexone6:22 AM Apr 24th via web
No existing drug modulates microglia but compounds exist which can do thisNIH research on this. #lowdosenaltrexone#bigonldn20106:25 AM Apr 24th via web
See Linda Watkins research on microglia and #lowdosenaltrexone#fibromyalgia #bigonldn20106:26 AM Apr 24th via web
Theory - #lowdosenaltrexone binds to hyper-sensitive receptors on microglia6:28 AM Apr 24th via web
Dr Jarred Younger's #lowdosenaltrexone fibromyalgia video presentationLive Q&A later. #bigonldn2010http://yfrog.com/64x7hj6:37 AM Apr 24th via Tweetie
New study - 30 women, mean age 43, no opiods, at least 6/10 on pain scale. #lowdosenaltrexone #bigonldn2010 #fibromyalgia6:39 AM Apr 24th via web
70% of #fibromyalgia patients had improvement, 50% much or very much improved on #lowdosenaltrexone (50%-75% pain reduced)#bigonldn6:41 AM Apr 24th via web
30% who had no improvement - ties in with 1st study, so consistent.#lowdosenaltrexone #bigonldn2010 #fibromyalgia6:42 AM Apr 24th via web
15% reduction in pain from placebo, additional 15% reduction due to #lowdosenaltrexone #bigonldn2010 #fibromyalgia6:43 AM Apr 24th via web
It seems that improvement persists to some extent even after#lowdosenaltrexone withdrawn. #fibromyalgia #bigonldn20106:44 AM Apr 24th via web
#lowdosenaltrexone tolerability = 89%, same as placebo in this#fibromyalgia studySo well very tolerated. #bigonldn20106:48 AM Apr 24th via web
#lowdosenaltrexone vivid dreams side-effect - 20% on placebo, 47% on LDN #bigonldn2010 Seldom disturbing dreams and tends to fade.6:49 AM Apr 24th via web
1 person dropped out of study and 1 person reduced from 5 to 3mg and did well on that. #lowdosenaltrexone #bigonldn20106:50 AM Apr 24th via web
Next steps - Further anlyses, long-term safety, mechanistic proof, optimisation #lowdosenaltrexone #fibromyalgia #bigonldn20106:51 AM Apr 24th via web
Researchers looking at levo-naltrexone and dextro-naltrexone (Left and Right parts of molecule) to optimise #lowdosenaltrexone#bigonldn20106:54 AM Apr 24th via web
Des from Fibromyalgia UK 'Very positive' on the new study results.#lowdosenaltrexone #bigonldn20106:55 AM Apr 24th via web
Skype link up with Dr Jarred Younger for Q&A being set-up now.#bigonldn2010 #lowdosenaltrexone #fibromyalgia6:59 AM Apr 24th via web
@tomgilhooly "#lowdosenaltrexone out of system in 18 hours" "Could be that effect is longer lasting" (Slow return of symptoms)#bigonldn20107:02 AM Apr 24th via web
@tomgilhooly "Study ties in with clinical experience" #bigonldn2010#lowdosenaltrexone #fibromyalgia7:03 AM Apr 24th via web
@tomgilhooly Talk of Levo/Dextro Naltrexone suggests pharma could make money out of new #Naltrexone-derived drug#bigonldn20107:04 AM Apr 24th via web
@tomgilhooly - Dextro-Naltrexone appears to be anti-inflammatory but not opiate receptor blooking #bigonldn2010#lowdosenaltrexone7:06 AM Apr 24th via web
Dr Jarred Younger - #lowdosenaltrexone and #fibromyalgia fatigue data mirrored the fatigue results very closely. #bigonldn20107:11 AM Apr 24th via web
Dosage was given 1 hour before retiring, 1 or 2 during day due to sleep problems. #lowdosenaltrexone #fibromyalgia #bigonldn20107:13 AM Apr 24th via web
Process of licensing levo and dextro naltrexone will take 'years'#bigonldn2010 #lowdosenaltrexone7:18 AM Apr 24th via web
@diamonDie presenting next on CFS/ME. #bigonldn2010 #CFS#ME #lowdosenaltrexone7:21 AM Apr 24th via web
People with CFS/ME often have many other infections and disease including auto-immune disease #bigonldn2010 #lowdosenaltrexone7:23 AM Apr 24th via web
Adrenal and other endocrine issues are also common#bigonldn2010 #lowdosenaltrexone7:23 AM Apr 24th via web
Symptoms started one day, fatigue, fever, hives, IBS, nausea, pain - feverish to this day #bigonldn2010 #lowdosenaltrexone7:24 AM Apr 24th via web
Even the smallest exertion required 24 hour restIn Finland CFS/ME is not recognised as an illness and virtually no treatment#bigonldn20107:25 AM Apr 24th via web
First heard of #lowdosenaltrexone in 2004, prescription in 2007 from Dr who had never heard of LDN #bigonldn20107:26 AM Apr 24th via web
Improvement in CFS/ME fatigue within 24 hours of#lowdosenaltrexone Much improved in first week, fever reduced#bigonldn20107:27 AM Apr 24th via web
Maija's Dr now treats many of his patients with #lowdosenaltrexoneImprovements reported from 50-70% improvement #bigonldn20107:28 AM Apr 24th via web
Patient - Could only walk '50m' now '3Km' Pain killers every day, now 1 every 2 weeks #lowdosenaltrexone #bigonldn20107:29 AM Apr 24th via web
#lowdosenaltrexone most effective for #CFS/ME but other drugs can help too. #bigonldn20107:31 AM Apr 24th via web
"Don't believe people who say there are no treatments [for CFS/ME]" #bigonldn2010 #lowdosenaltrexone7:32 AM Apr 24th via web
Maija's book on Amazon - http://bit.ly/coFtLV #bigonldn2010#lowdosenaltrexone #CFS/ME7:33 AM Apr 24th via web
Next up - Christine Fowler Chronic Fatigue Syndrome patient.#bigonldn2010 #lowdosenaltrexone7:36 AM Apr 24th via web
Don't let @diamondie fool you - she did great!7:36 AM Apr 24th via web
Christine on #lowdosenaltrexone - Now active, back to work as normal and much, much improvedLess tired. #bigonldn2010#CFS/ME7:38 AM Apr 24th via web
After 12 years of #CFS/ME on 75mg #lowdosenaltrexonerecommending anyone try it, 'shouting from the rooftops'#bigonldn20107:39 AM Apr 24th via web
Negatives - Memory still less effective and still more stressed than before #lowdosenaltrexoe #CFS/ME7:40 AM Apr 24th via web
@tomgilhooly now on #CCSVI and #lowdosenaltrexone as complimentary therapies. #bigonldn20108:10 AM Apr 24th via web
Dr Tom believes CCSVI may feed into fibromyalgia and CFS/MS too#bigonldn2010 #lowdosenaltrexone8:13 AM Apr 24th via web
Chronic Cerebrospinal Venous Insufficiency - newly identified venous conditionInternational Union of Phlebology 2009#bigonldn20108:14 AM Apr 24th via web
IUoP voted that #CCSVI was new condition #bigonldn20108:15 AM Apr 24th via web
@tomgilhooly presenting on CCSVI and #lowdosenaltrexone#bigonldn2010 http://yfrog.com/bavo4j8:18 AM Apr 24th via Tweetie
Iron Deposition in brain seen in dementia/Parkinson's and MS also in scans. #bigonldn2010 #CCSVI8:21 AM Apr 24th via web
Zivadino et al - Amount of iron deposits related to severity of MS, April 2010 #CCSVI #bigonldn20108:22 AM Apr 24th via web
Unlike #lowdosenaltrexone the MS Society in Italy are funding research (UK one isn't) and researchers are engaged.#bigonldn2010 #CCSVI8:24 AM Apr 24th via web
Zamboni April 2009 #CCSVI found in 90% of #MS patients studied.#bigonldn20108:25 AM Apr 24th via web
Zamboni Dec 2009 65 MS patient, 50% reduction in MRI lesions#CCSVI #bigonldn20108:26 AM Apr 24th via web
@rachelcreative Glad you're following and enjoying today.#bigonldn20108:27 AM Apr 24th via web in reply to rachelcreative
Zivadinov 2010 - 38% patients with single MS episode had CCSVI; 22% of non MS patients CCSVI ; 80% of severe MS patients CCSVI#bigonldn20108:29 AM Apr 24th via web
Doppler scan better than MRI for visualising #CCSVI#bigonldn20108:31 AM Apr 24th via web
A stent is a life-long procedure and complications can be serious - Venous stent can migrate to the heart #CCSVI #bigonldn20108:32 AM Apr 24th via web
CT Venogram is chosen imaging method by @tomgilhooly for#CCSVI #bigonldn20108:33 AM Apr 24th via web
#CCSVI and #lowdosenaltrexone - CCSVI is a distinct conditionIron deposit, blood/brain barrier breakdown. #bigonldn20108:34 AM Apr 24th via web
#lowdosenaltrexone immune modulator #CCSVI reduce immune stimulationNutrition important too. #bigonldn @tomgilhooly8:35 AM Apr 24th via web
#MS nutrition recommendations - Omega 3, Vitamin D, dairy-free, Inosine (Cut down Omega 6) #bigonldn2010 @tomgilhooly8:37 AM Apr 24th via web
#CCSVI - larger group of patients interested than in#lowdosenaltrexone #bigonldn20108:37 AM Apr 24th via web
#CCSVI - new condition ; Co-exists with #MS Treatment complements #lowdosenaltrexone #bigonldn2010 @tomgilhooly8:39 AM Apr 24th via web
#CCSVI risks - greatest with stent + blood thinners but still low.#bigonldn2010 @tomgilhooly8:42 AM Apr 24th via web
#CCSVI risks - new condition but treatment procedure is not a new one, proven. #bigonldn2010 @tomgilhooly8:43 AM Apr 24th via web
#CCSVI treatment very over-subscribed, a waiting list is going to be created@tomgilhooly #bigonldn20108:43 AM Apr 24th via web
#CCSVI procedure from @tomgilhooly will be cheaper than going to Poland for treatment. #bigonldn20108:47 AM Apr 24th via web
#CCSVI ultimate aim is to get procedure on the NHS in UK but need data #bigonldn2010 @tomgilhooly8:47 AM Apr 24th via web
RT @nobleday: @LDNNow SAM-e is another useful suppliment.8:55 AM Apr 24th via web
@fuwoyips EU #lowdosenaltrexone conference coverage at#bigonldn2010 hashtag8:56 AM Apr 24th via web in reply to fuwoyips
2nd European #lowdosenaltrexone conference coming to and endThanks for reading the coverage and see you again next year.#bigonldn20109:00 AM Apr 24th via web
@tomgilhooly #lowdosenaltrexone momentum from patients 'unstopable' #bigonldn20109:01 AM Apr 24th via web
Crohn's disease costs New Zealand ~ $74 milion a year in healthcare costs for around 100,000 patients.A case for#lowdosenaltrexone? #ldnnowabout 22 hours ago via web
Patient with Hashimoto's on #lowdosenaltrexone -http://proposals.yourcountryyourcall.com/ct/ct_a_view_idea.bix?i=58C09504about 19 hours ago via web
@YahooAnswersNow See @LDNNow tweets from the European#lowdosenaltrexone conference#bigonldn2010 Fibro trial results published #ldnnowabout 13 hours ago via web in reply to YahooAnswersNow
Thursday, 4 March 2010
Scottish Parliament Low Dose Naltrexone (LDN) NHS Availability Petition Update
The petition to the Scottish Parliament Public Petitions Committee, calling on the Scottish Government to ensure that Low Dose Naltrexone (LDN) to be made available to all on the NHS has passed its first milestone.
At the second meeting considering it, the committee accepted the petition cannot be closed and continues to be pursued.
The committee are writing to the Department of Health and The Scottish Government.
You can view the question being asked of these bodies here -
http://bit.ly/SPLDNQs
All the documents received by the committee in response to their first round of correspondence are here -
http://bit.ly/SPLDNdocs
At the second meeting considering it, the committee accepted the petition cannot be closed and continues to be pursued.
The committee are writing to the Department of Health and The Scottish Government.
You can view the question being asked of these bodies here -
http://bit.ly/SPLDNQs
All the documents received by the committee in response to their first round of correspondence are here -
http://bit.ly/SPLDNdocs
The 2nd European Low Dose Naltrexone (LDN) Conference, Glasgow 24th April
You can register for the 2nd EU LDN Conference here -
http://www.bigonldn2010.com/
Watch the introductory video by Dr Tom Gilhooly where he talks of the work of LDN Now coming out of the 2009 conference
http://ldnnow.com
http://www.bigonldn2010.com/
Watch the introductory video by Dr Tom Gilhooly where he talks of the work of LDN Now coming out of the 2009 conference
http://ldnnow.com
Thursday, 28 January 2010
Great New Low Dose Naltrexone (LDN) Science Site
A brilliant one-stop resource for scientific information on Low Dose Naltrexone (LDN).
A good one to give to skeptical doctors.
There's a newsletter you can sign up to too.
http://www.ldnscience.org
A good one to give to skeptical doctors.
There's a newsletter you can sign up to too.
http://www.ldnscience.org
Thursday, 7 January 2010
NEW European Parliament Level Petition for Low Dose Naltrexone Research Funding
Please consider signing this petition and passing it on.
NOTE - NO donation is required to the petition site, after filling in your details on the first page you have signed the petition and can leave the site without donating. Any donations that are made do not go to LDN Now or the EU government but rather to the petitions site.
NOTE - This petition is open to anyone, anywhere, not just EU citizens.
Thanks.
http://www.ipetitions.com/petition/ldnnow/
NOTE - NO donation is required to the petition site, after filling in your details on the first page you have signed the petition and can leave the site without donating. Any donations that are made do not go to LDN Now or the EU government but rather to the petitions site.
NOTE - This petition is open to anyone, anywhere, not just EU citizens.
Thanks.
http://www.ipetitions.com/petition/ldnnow/
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